Based on data from a survey of biological scientists at 125 American universities, this article explores how the commercialization of the university affects the problems academic scientists pursue and argues that this reorientation of scientific agendas results in a shift from science in the public interest to science for private goods. Drawing on perspectives from Bourdieu on how actors employ strategic practices toward the accumulation of social capital and acquire dispositional and perceptional tendencies that in turn recondition social structures, the (...) commercialization of the university is construed not as something that ‘‘happens to,’’ but rather something that ‘‘happens through’’ academic scientists. The specific shape and direction of the commercialization of the university is therefore influenced by how scientists incorporate the new resources and social relations of commercialization into their scientific practice and how their creative engagement with shifting structural conditions remakes the culture of academic science. (shrink)

Although trustworthiness has been described as a source of competitive advantage, its value extends to organizational governance and wealth creation. We identify the importance of the commitment—compliance continuum in the decision to trust and note that trustworthiness is a subjective perception viewed through each person's mediating lens. That lens and each person's interpretation of the social contract impact one's commitment to cooperate. We suggest five propositions that integrate trustworthiness, governance, and wealth creation.

As is the case with most pre‐modern philosophers of India, very little historical information is available about Bhartṛ‐hari. There are many interesting legends, some turned into extensive plays and poems, current about him. However, it is impossible to determine on their basis even whether there was only one philosopher called Bhartṛ‐hari. The appellation “philosopher” could unquestionably be applied to the author or authors of at least two Sanskrit works that are commonly ascribed to Bhartṛ‐hari.

Neuroconstructivism: How the Brain Constructs Cognition proposes a unifying framework for the study of cognitive development that brings together (1) constructivism (which views development as the progressive elaboration of increasingly complex structures), (2) cognitive neuroscience (which aims to understand the neural mechanisms underlying behavior), and (3) computational modeling (which proposes formal and explicit specifications of information processing). The guiding principle of our approach is context dependence, within and (in contrast to Marr [1982]) between levels of organization. We propose that three (...) mechanisms guide the emergence of representations: competition, cooperation, and chronotopy; which themselves allow for two central processes: proactivity and progressive specialization. We suggest that the main outcome of development is partial representations, distributed across distinct functional circuits. This framework is derived by examining development at the level of single neurons, brain systems, and whole organisms. We use the terms encellment, embrainment, and embodiment to describe the higher-level contextual influences that act at each of these levels of organization. To illustrate these mechanisms in operation we provide case studies in early visual perception, infant habituation, phonological development, and object representations in infancy. Three further case studies are concerned with interactions between levels of explanation: social development, atypical development and within that, developmental dyslexia. We conclude that cognitive development arises from a dynamic, contextual change in embodied neural structures leading to partial representations across multiple brain regions and timescales, in response to proactively specified physical and social environment. (shrink)

We report the identification of a recurrent, 520-kb 16p12.1 microdeletion associated with childhood developmental delay. The microdeletion was detected in 20 of 11,873 cases compared with 2 of 8,540 controls and replicated in a second series of 22 of 9,254 cases compared with 6 of 6,299 controls. Most deletions were inherited, with carrier parents likely to manifest neuropsychiatric phenotypes compared to non-carrier parents. Probands were more likely to carry an additional large copy-number variant when compared to matched controls. The clinical (...) features of individuals with two mutations were distinct from and/or more severe than those of individuals carrying only the co-occurring mutation. Our data support a two-hit model in which the 16p12.1 microdeletion both predisposes to neuropsychiatric phenotypes as a single event and exacerbates neurodevelopmental phenotypes in association with other large deletions or duplications. Analysis of other microdeletions with variable expressivity indicates that this two-hit model might be more generally applicable to neuropsychiatric disease. © 2010 Nature America, Inc. All rights reserved. (shrink)

© 2015, Springer-Verlag Berlin Heidelberg.Genetic studies have identified single nucleotide polymorphisms associated with the risk of prostate cancer. It remains unclear whether such genetic variants are associated with disease aggressiveness. The NCI-SPORE Genetics Working Group retrospectively collected clinicopathologic information and genotype data for 36 SNPs which at the time had been validated to be associated with PC risk from 25,674 cases with PC. Cases were grouped according to race, Gleason score and aggressiveness. Statistical analyses were used to compare the frequency (...) of the SNPs between different disease cohorts. After adjusting for multiple testing, only PC-risk SNP rs2735839 was significantly and inversely associated with aggressive and high-grade disease in European men. Similar associations with aggressive and high-grade disease were documented in African-American subjects. The G allele of rs2735839 was associated with disease aggressiveness even at low PSA levels in both European and African-American men. Our results provide further support that a PC-risk SNP rs2735839 near the KLK3 gene on chromosome 19q13 may be associated with aggressive and high-grade PC. Future prospectively designed, case-case GWAS are needed to identify additional SNPs associated with PC aggressiveness. (shrink)

We applaud Ray and Cooper (2024) for emphasizing environmental health as a bioethics issue. As a team of interdisciplinary pediatric researchers and providers who are part of an institutional clima...

A shift from a metaphysical framework of substance to one of process enables an integrated account of the emergence of normative phenomena. I show how substance assumptions block genuine ontological emergence, especially the emergence of normativity, and how a process framework permits a thermodynamic-based account of normative emergence. The focus is on two foundational forms of normativity, that of normative function and of representation as emergent in a particular kind of function. This process model of representation, called interactivism, compels changes (...) in many related domains. The discussion ends with brief attention to three domains in which changes are induced by the representational model: perception, learning, and language. (shrink)

This article focuses on the problem of representational content. Accounting for representational content is the central issue in contemporary naturalism: it is the major remaining task facing a naturalistic conception of the world. Representational content is also the central barrier to contemporary cognitive science and artificial intelligence: it is not possible to understand representation in animals nor to construct machines with genuine representation given current (lack of) understanding of what representation is. An elaborated critique is offered to current approaches to (...) representation, arguing that the basic underlying approach is, at root, logically incoherent, and, thus, that standard approaches are doomed to failure. An alternative model of representation - interactivism - is presented that avoids or solves the problems facing standard approaches. Interactivism is framed by a version of functionalism, and a naturalization of that functionalism completes an outline of a naturalization of representation and representational content. (shrink)

* This paper was to have been written jointly with Don Campbell. His tragic death on May 6, 1996, occurred before we had been able to do much planning for the paper. As a result, this is undoubtedly a very different paper than if Don and I had written it together, and, undoubtedly, not as good a paper. Nevertheless, I believe it maintains at least the spirit of what we had discussed. Clearly, all errors are mine alone.

Emergence seems necessary for any naturalistic account of the world — none of our familiar world existed at the time of the Big Bang, and it does now — and normative emergence is necessary for any naturalistic account of biology and mind — mental phenomena, such as representation, learning, rationality, and so on, are normative. But Jaegwon Kim’s argument appears to render causally efficacious emergence impossible, and Hume’s argument appears to render normative emergence impossible, and, in its general form, it (...) precludes any emergence at all. I argue that both of these barriers can be overcome, and, in fact, that they each constitute reductios of their respective underlying presuppositions. In particular, causally efficacious ontological emergence can be modeled, but only within a process metaphysics, thus avoiding Kim’s argument, and by making use of non-abbreviatory forms of definition, thus avoiding Hume’s argument. I illustrate these points with models of the emergent nature of normative function and of representation. (shrink)

The interactivist model has explored a number of consequences of process metaphysics. These include reversals of some fundamental metaphysical assumptions dominant since the ancient Greeks, and multiple further consequences throughout the metaphysics of the world, minds, and persons. This article surveys some of these consequences, ranging from issues regarding entities and supervenience to the emergence of normative phenomena such as representation, rationality, persons, and ethics.

In this chapter, I outline dynamic models of motivation and emotion. These turn out not to be autonomous subsystems, but, instead, are deeply integrated in the basic interactive dynamic character of living systems. Motivation is a crucial aspect of particular kinds of interactive systems -- systems for which representation is a sister aspect. Emotion is a special kind of partially reflective interaction process, and yields its own emergent motivational aspects. In addition, the overall model accounts for some of the crucial (...) properties of consciousness. (shrink)

The dominant assumptions -- throughout contemporary philosophy, psychology, cognitive science, and artificial intelligence -- about the ontology underlying intentionality, and its core of representationality, is that of encodings -- some sort of informational or correspondence or covariation relationship between the represented and its representation that constitutes that representational relationship. There are many disagreements concerning details and implementations, and even some suggestions about claimed alternative ontologies, such as connectionism (though none that escape what I argue is the fundamental flaw in these (...) dominant approaches). One assumption that seems to be held by all, however, usually without explication or defense, is that there is _one_ singular underlying ontology to representationality. In this paper, I argue that there are in fact quite a number of ontologies that manifest representationality -- levels of representationality -- and that _none_ of them are the standard "manipulations of encoded symbols" ontology, nor any other variation on the informational approach to representation. Collectively, these multiple representational ontologies constitute a framework for cognition, whether natural or artificial. (shrink)

A final version of this paper is in press as: Bickhard, M. H.. The Dynamic Emergence of Representation. In H. Clapin, P. Staines, P. Slezak Representation in Mind: New Approaches to Mental Representation. Praeger.

In this fresh and powerfully argued book, Mark Bernstein identifies the qualities that make an entity deserving of moral consideration. It is frequently assumed that only (normal) human beings count. Bernstein argues instead for "experientialism"--the view that having conscious experiences is necessary and sufficient for moral standing. He demonstrates that this position requires us to include many non-human animals in our moral realm, but not to the extent that many deep ecologists champion.

I will argue that social ontology is constituted as hierarchical and interlocking conventions of multifarious kinds. Convention, in turn, is modeled in a manner derived from that of David K. Lewis. Convention is usually held to be inadequate for models of social ontologies, with one primary reason being that there seems to be no place for normativity. I argue that two related changes are required in the basic modeling framework in order to address this (and other) issue(s): (1) a shift (...) to an intentional model—among other reasons, in order to account for normativity—and (2) moving away from the belief-desire, propositional attitude, framework for understanding the intentional realm toward an interactive, pragmatic model of intentionality. These shifts provide natural approaches to: (1) understanding the normativities of social realities; (2) the sense in which social ontology is often constituted in implicit relations among the participants rather than elaborated and iterated explicit beliefs and desires; (3) and language. (shrink)

The first paper in this pair (Bickhard in Axiomathes, 2015) developed a model of the nature of representation and cognition, and argued for a model of the micro-functioning of the brain on the basis of that model. In this sequel paper, starting with part III, this model is extended to address macro-functioning in the CNS. In part IV, I offer a discussion of an approach to brain functioning that has some similarities with, as well as differences from, the model presented (...) here: sometimes called the Predictive Brain approach. (shrink)

Two challenges to the very possibility of emergence are addressed, one metaphysical and one logical. The resolution of the metaphysical challenge requires a shift to a process metaphysics, while the logical challenge highlights normative emergence, and requires a shift to more powerful logical tools -- in particular, that of implicit definition. Within the framework of a process metaphysics, two levels of normative emergence are outlined: that of function and that of representation.

An interactive process model of the nature of representation intrinsically accounts for multiple emergent properties of consciousness, such as being a contentful experiential flow, from a situated and embodied point of view. A crucial characteristic of this model is that content is an internally related property of interactive process, rather than an externally related property as in all other contemporary models. Externally related content requires an interpreter, yielding the familiar regress of interpreters, along with a host of additional fatal problems. (...) Further properties of consciousness, such as differentiated qualities of experience, including qualia, emerge with conscious reflection. In particular, qualia are not constituents or direct properties of consciousness per se. Assuming that they are so is a common and ultimately disastrous misconstrual of the problems of consciousness. (shrink)

Persons are biological beings who participate in social environments. Is human sociality different from that of insects? Is human sociality different from that of a computer or robot with elaborate rules for social interaction in its program memory? What is the relationship between the biology of humans and the sociality of persons? I argue that persons constitute an emergent ontological level that develops out of the biological and psychological realm, but that is largely social in its own constitution. This requires (...) a characterization of the relationships between the bio/psychological and the social, and of the developmental process of emergence. It also requires a framework for modeling the bio/psychological level that makes any such emergence possible. Neither attachment theory nor information processing frameworks, for example, will do — the major orientations toward human sociality today make understanding that sociality ultimately impossible. Only an action framework, such as that of Peirce or Piaget2, suffices. (shrink)

We all believe an unbounded number of things about the way the world is and about the way the world works. For example, I believe that if I move this book into the other room, it will not change color -- unless there is a paint shower on the way, unless I carry an umbrella through that shower, and so on; I believe that large red trucks at high speeds can hurt me, that trucks with polka dots can hurt me, (...) and so on; that if I move this book, the room will stay in place -- unless there is a pressure switch under the book attached to a bomb, unless the switch communicates to the bomb by radio and there is shielding in the way, and so on; that the moon is not made of green cheese, that the moon is not made of caviar, that the moon is not made of gold, and so on. The problems involved in accounting for such infinite proliferations of beliefs -- and the computations and inferences that take them into account -- are collectively called the Frame Problems, and are considered by some to constitute a major discovery of a new philosophical problem. How could we possibly learn them all? How could the brain possibly hold them all? The problems appear insoluble, impossible. Yet we all learn and hold such unbounded numbers of beliefs; in particular, children do. Something must be wrong. I wish to argue that the frame problem arises from a fundamental presupposition about the nature of representation -- a false presupposition. Yet, it is a presupposition that dominates contemporary developmental psychology (and psychology more broadly, and cognitive science, artificial intelligence, philosophy of mind, and so on). In particular, I will offer an alternative model of the nature of representation within which the frame problem does not arise -- within which such unboundedness is natural. (shrink)

Standard semantic information processing models—information in; information processed; information out —lend themselves to standard models of the functioning of the brain in terms, e.g., of threshold-switch neurons connected via classical synapses. That is, in terms of sophisticated descendants of McCulloch and Pitts models. I argue that both the cognition and the brain sides of this framework are incorrect: cognition and thought are not constituted as forms of semantic information processing, and the brain does not function in terms of passive input (...) processing units organized as neural nets. An alternative framework is developed that models cognition and thought not in terms of semantic information processing, and, correspondingly, models brain functional processes also not in terms of semantic information processing. As alternative to such models: I outline a pragmatist oriented, interaction based, model of representation; derive from this model a fundamental framework of constraints on how the brain must function; show that such a framework is in fact found in the brain, and develop the outlines of a broader model of how mental processes can be realized within this alternative framework. Part I of this discussion focuses on some criticisms of standard modeling frameworks for representation and cognition, and outlines an alternative interactivist, pragmatist oriented, model. In part II, the focus is on the fact that the brain does not, in fact, function in accordance with standard passive input processing models—e.g., information processing models. Instead, there are multiple endogenously active processes at multiple spatial and temporal scales across multiple kinds of cells. A micro-functional model that accounts for, and even predicts, these multi-scale phenomena in generating emergent representation and cognition is outlined. That is, I argue that the interactivist model of representation outlined offers constraints on how the brain should function that are in fact empirically found, and, in reverse, that the multifarious details of brain functioning entail the pragmatist representational model—a very strong interrelationship. In the sequel paper, starting with part III, this model is extended to address macro-functioning in the CNS. In part IV, I offer a discussion of an approach to brain functioning that has some similarities with, as well as differences from, the model presented here: sometimes called the predictive brain approach. (shrink)

Function emerges in certain kinds of far-from-equilibrium systems. One important kind of function is that of interactive anticipation, an adaptedness to temporal complexity. Interactive anticipation is the locus of the emergence of normative representational content, and, thus, of representation in general: interactive anticipation is the naturalistic core of the evolution of cognition. Higher forms of such anticipation are involved in the subsequent macro-evolutionary sequence of learning, emotions, and reflexive consciousness.

Information and representation are thought to be intimately related. Representation, in fact, is commonly considered to be a special kind of information. It must be a _special_ kind, because otherwise all of the myriad instances of informational relationships in the universe would be representational -- some restrictions must be placed on informational relationships in order to refine the vast set into those that are truly representational. I will argue that information in this general sense is important to genuine agents, but (...) that it is a blind alley with regard to the attempt to understand representation. On the other hand, I will also argue that a different, quite non-standard, form of information is central to genuine representation. First I turn to some of the reasons why information as usually considered is the wrong category for understanding representation; second to an alternative model of representation -- one that is naturally emergent in autonomous agents, and that does involve information, but not in any standard form; and third I return to standard notions of informational relationships and show what they are in fact useful for. (shrink)

Received opinion has it that humans are morally superior to non-human animals; human interests matter more than the like interests of animals and the value of human lives is alleged to be greater than the value of nonhuman animal lives. Since this belief causes mayhem and murder, its de-mythologizing requires urgent attention.

I will argue that mechanism is not sufficient to capture representation, thus cognition. More generally, mechanism is not sufficient to capture normativity of any sort. I will also outline a model of emergent normativity, representational normativity in particular, and show how it transcends these limitations of mechanism. To begin, I will address some illustrative attempts to model representation within mechanistically naturalistic frameworks, first rather generally, and then in the cases of the models of Fodor and Millikan.

The principle of gratuitous suffering -- The value of humans and the value of animals -- The holocaust of factory farming -- Hunting -- Animal experimentation -- The law and animals -- Women and animals.

How Does the Environment Affect the Person? Mark H. Bickhard invited chapter in Children's Development within Social Contexts: Metatheoretical, Theoretical and Methodological Issues, Erlbaum. edited by L. T. Winegar, J. Valsiner, in press.

Internal relations are those relations that are intrinsic to the nature of one or more of the relata. They are a kind of essential relation, rather than an essential property. For example, an arc of a circle is internally related to the center of that circle in the sense that.

neglected aspect: knowledge of error, or ‘‘negative’’ knowledge. The development of knowledge of what counts as error occurs via a kind of internal variation and selection, or quasi-evolutionary, process. Processes of reflection generate a hierarchy of principles of error.

Operational definitions were a neo-Machean development that connected with the positivism of Logical Positivism. Logical Positivism failed, with the failure of operational definitions being just one of multiple and multifarious failures of Logical Positivism more broadly. Operationalism, however, has continued to seduce psychology more than half a century after it was repudiated by philosophers of science, including the very Logical Positivists who had first taken it seriously. It carries with it a presupposed metaphysics that is false in virtually all of (...) its particulars, and thereby distorts and obscures genuine issues concerning the nature of theory and of science. It makes it particularly difficult for psychologists, under the thrall of this dogma, to free themselves from these false presuppositions, and to think about, create, and critique genuine scientific theory and process. That is the tragedy of operationalism. (shrink)

assumptions about the phenomena of interest with process models. Thus, phlogiston has been replaced by combustion, caloric by random thermal motion, and vital fluid by far- from-equilibrium self-reproducing organizations of process. The most significant exceptions to this historical pattern are found in studies of the mind. Here, substance assumptions are still ubiquitous, ranging from models of representation to those of emotions to personality and psychopathology. Substance assumptions do pernicious damage to our ability to understand such phenomena. In this discussion, I (...) will focus on the problem of representation. (shrink)